Eltrombopag Impurity 91 CAS CATO-C4X-119891
| CAS No. | CATO-C4X-119891 |
| Molecular Formula | C13H10BrNO3 |
| Molecular Weight | 308.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Eltrombopag Impurity 91 (CAS CATO-C4X-119891), a pharmacopoeial impurity reference standard (molecular formula C13H10BrNO3, MW 308.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Eltrombopag Impurity 91 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 308.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H10BrNO3 |
| Molecular Weight | 308.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 82 (CAS 725241-64-5)
- Eltrombopag Impurity 15 (CAS CATO-C4X-119815)
- Eltrombopag Impurity 87 (CAS CATO-C4X-119887)
- Eltrombopag Impurity 41 (CAS 303730-26-9)
- Eltrombopag Impurity 136 (CAS CATO-C4X-1198136)
- Eltrombopag Impurity 100 (CAS 15969-09-2)
- Eltrombopag Impurity 14 (CAS CATO-C4X-119814)
- Eltrombopag Impurity 13 (CAS 376592-58-4)
Recommended Standards
- Resorantel (CAS 20788-07-2)
- Quinoxyfen (CAS 124495-18-7)
- N-(5-Bromo-6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)acetamide (CAS 74856-68-1)
- (R)-2-(3-bromo-5-(trifluoromethyl)phenyl)piperidine (CAS 1270205-41-8)
- Naltrexone impurity 43 (CAS CATO-C4X-147543)
- Epinastine Impurity 20 (CAS CATO-C4X-184020)
- Alogliptin Impurity 3 (CAS 1108731-49-2)
- 1-methyl-3,5-bis(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 1375187-56-6)
- 6-Amino-4-methylnicotinamide (CAS 65169-39-3)
- Ethyl (2-((3-cyano-6-(3,4-dimethoxyphenyl)-4-(trifluoromethyl)pyridin-2-yl)thio)acetyl)carbamate (CAS 939893-62-6)
- 2-(4-(2-Hydroxy-3-(morpholinoamino)propoxy)phenyl)acetamide (CAS 866150-98-3)
- Sulfisoxazole-13C6 (CAS 1334378-46-9)
- 4-Methyl-N-((5-(thiophen-2-yl)isoxazol-3-yl)methyl)-1,2,3-thiadiazole-5-carboxamide (CAS 1207023-47-9)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
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