Eltrombopag Impurity 83 CAS CATO-C4X-119883
| CAS No. | CATO-C4X-119883 |
| Molecular Formula | C12H13N3O2 |
| Molecular Weight | 231.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Eltrombopag Impurity 83 (CAS CATO-C4X-119883, C12H13N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Eltrombopag Impurity 83 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 231.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13N3O2 |
| Molecular Weight | 231.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Eltrombopag Standards
- Eltrombopag Impurity 56 (CAS CATO-C4X-119856)
- Eltrombopag Impurity 84 (CAS CATO-C4X-119884)
- Eltrombopag Impurity 85(E-Isomer) (CAS CATO-C4X-119885)
- Eltrombopag Impurity 9 (CAS CATO-C4X-11989)
- Eltrombopag Impurity 98(Z-Isomer) (CAS CATO-C4X-119898)
- Eltrombopag Impurity 32 (CAS 98775-19-0)
- Eltrombopag Impurity 36 (CAS 33696-00-3)
- Eltrombopag Impurity 38 (CAS 500298-30-6)
Recommended Standards
- Ticagrelor Impurity 158 (CAS 1402150-27-9)
- Moxifloxacin Impurity 95 (CAS 71083-22-2)
- Moxifloxacin impurity 160 (CAS 1415319-29-7)
- Mirabegron impurity 119 (CAS CATO-C4X-1032119)
- Nikethamide Impurity 8 (CAS 530-40-5)
- Lenvatinib Impurity 181 (CAS CATO-C4X-1140181)
- Brovudine Dimer Impurity 11 (CAS CATO-C4X-275811)
- 2-((4-Chloro-N-(4-chlorophenyl)phenyl)sulfonamido)-N-phenylacetamide (CAS 337922-00-6)
- 6,7-Dihydro-5H-cyclopenta[b]pyridin-5-amine (CAS 535935-84-3)
- 4-(5-(4-Methoxyphenyl)oxazol-2-yl)aniline (CAS 10004-75-8)
- N,3,5-Trimethyl-1H-pyrazol-4-amine hydrochloride (CAS 1332528-26-3)
- Rasagiline Impurity 75 HCl (CAS 1016719-48-4 (free base))
- 3-((2,6-Dichlorobenzyl)thio)-N-phenylthiophene-2-carboxamide (CAS 251097-42-4)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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