Posaconazole Impurity 277 CAS CATO-C4X-1208277
| CAS No. | CATO-C4X-1208277 |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Posaconazole Impurity 277.
Posaconazole Impurity 277 (CAS CATO-C4X-1208277) is a certified pharmaceutical impurity reference standard with the molecular formula C13H20N2O2C2H2O4 and a molecular weight of 326.35 g/mol.
Posaconazole Impurity 277 (C13H20N2O2C2H2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20N2O2 C2H2O4 |
| Molecular Weight | 326.35 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Posaconazole Standards
- Posaconazole Impurity 25 (CAS 1042398-26-4)
- Posaconazole Impurity 112 (CAS 110931-77-6)
- Posaconazole Impurity 111 (CAS 112559-81-6)
- Posaconazole-d4 (CAS 1133712-26-1)
- Posaconazole Impurity 84 (CAS 122151-32-0)
- Posaconazole Impurity 115 (CAS 122151-38-6)
- Posaconazole Impurity 67(R,S,R,R) (CAS 1229428-89-0)
- Posaconazole Impurity 22(R,S,S,R) (CAS 1229428-90-3)
Recommended Standards
- Tryptophan EP Impurity H (CAS 6052-68-2)
- Eravacycline Impurity 7(TP-498） (CAS CATO-C4X-29387)
- Olopatadine Impurity 36 HCl (CAS CATO-C4X-171836)
- (1-[Trifluoromethyl]cyclopentyl)benzene (CAS 1186195-43-6)
- (S)-Ethyl 3-(3-bromophenyl)-2-((tert-butoxycarbonyl)amino)propanoate (CAS 1159502-91-6)
- 2-(4-Chlorophenyl)-1H-indene-1,3(2H)-dione (CAS 1146-99-2)
- 7,8-Difluoroquinolin-3-ol (CAS 1314012-52-6)
- (1S)-1-(4-fluoro-3-methylphenyl)propan-1-ol (CAS 1175913-39-9)
- Sodium stannate (CAS 12058-66-1)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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