Ixazomib Impurity 23 CAS CATO-C4X-126723
| CAS No. | CATO-C4X-126723 |
| Molecular Formula | C9H6Cl3NO3 |
| Molecular Weight | 282.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ixazomib Impurity 23 (CAS CATO-C4X-126723, C9H6Cl3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ixazomib Impurity 23 (C9H6Cl3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 282.51 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6Cl3NO3 |
| Molecular Weight | 282.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ixazomib Standards
- Ixazomib Impurity 21 (CAS CATO-C4X-126721)
- Ixazomib Impurity 41 (CAS CATO-C4X-126741)
- Ixazomib Impurity 88 (CAS CATO-C4X-126788)
- Ixazomib Impurity 69 (CAS 121-48-2)
- Ixazomib Impurity 61 (CAS CATO-C4X-126761)
- Ixazomib Impurity 80 (CAS CATO-C4X-126780)
- Ixazomib Impurity 63 (CAS CATO-C4X-126763)
- Ixazomib Impurity 67 (CAS 1012-84-6)
Recommended Standards
- N-1,3-benzodioxol-5-yl-2,2,2-trichloroacetamide (CAS 549543-76-2)
- 3,5-Dichloro-2-(2-chloro-acetylamino)-benzoic acid (CAS 39263-98-4)
- Tulobuterol Impurity 35 (CAS 1597775-10-4)
- 2-Chloro-5-iodo-4,6-dimethylpyridin-3-amine (CAS 2197057-54-6)
- Dapagliflozin Impurity 192 (CAS CATO-C4X-1138192)
- Icatibant Impurity 1 TFA salt (CAS CATO-C4X-23611)
- Cetirizine Dihydrochloride EP Impurity E (CAS CATO-C4X-108351)
- 1-(1,5-dimethyl-1h-pyrazole-3-carbonyl)piperazine (CAS 1177310-79-0)
- 6-methyl-n-(propan-2-yl)pyridin-2-amine (CAS 428820-85-3)
- 2-(Chloromethyl)-4-(difluoromethyl)-6-hydroxy-3-(trifluoromethyl)pyridine (CAS 1806978-36-8)
- 3-Bromo-5-cyclopropoxy-N,N-dimethylpyridin-2-amine (CAS 1243346-59-9)
- Gedunin (CAS 2753-30-2)
- 4-(Decylamino)butanoic acid hydrochloride (CAS 1376391-99-9)
- Insulin Degludec Impurity 6 (CAS CATO-C4X-21576)
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