Ixazomib Impurity 21 CAS CATO-C4X-126721
| CAS No. | CATO-C4X-126721 |
| Molecular Formula | C9H6Cl3NO3 |
| Molecular Weight | 282.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Ixazomib Impurity 21 (CAS CATO-C4X-126721), a pharmacopoeial impurity reference standard (molecular formula C9H6Cl3NO3, MW 282.51 g/mol) used for the identification and quantification of trace impurities in APIs.
Ixazomib Impurity 21 (C9H6Cl3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6Cl3NO3 |
| Molecular Weight | 282.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ixazomib Standards
- Ixazomib Impurity 23 (CAS CATO-C4X-126723)
- Ixazomib Impurity 41 (CAS CATO-C4X-126741)
- Ixazomib Impurity 88 (CAS CATO-C4X-126788)
- Ixazomib Impurity 69 (CAS 121-48-2)
- Ixazomib Impurity 61 (CAS CATO-C4X-126761)
- Ixazomib Impurity 80 (CAS CATO-C4X-126780)
- Ixazomib Impurity 63 (CAS CATO-C4X-126763)
- Ixazomib Impurity 67 (CAS 1012-84-6)
Recommended Standards
- N-1,3-benzodioxol-5-yl-2,2,2-trichloroacetamide (CAS 549543-76-2)
- 3,5-Dichloro-2-(2-chloro-acetylamino)-benzoic acid (CAS 39263-98-4)
- 2-Chloro-5-iodo-4,6-dimethylpyridin-3-amine (CAS 2197057-54-6)
- 2-(2,2,2-Trichloroacetamido)benzoic acid (CAS 4257-77-6)
- Trelagliptin Impurity 25 (CAS CATO-C4X-104625)
- Levocarnitine impurity 28 (CAS 256928-74-2)
- Nifuratel Impurity 12 (CAS 65019-14-9)
- 1-Bromo-4-(1-iodoethenyl)benzene (CAS 690274-80-7)
- 1-(Tert-butyl) 2-methyl 5-aminopiperidine-1,2-dicarboxylate (CAS 1779439-20-1)
- Ferric Carboxymaltose (CAS 9007-72-1)
- Roxadustat Impurity N2 (CAS 57830-14-5)
- 2-(Aminomethyl)-3-(difluoromethyl)-6-iodo-5-methoxypyridine (CAS 1805088-06-5)
- 6-Isopropylindoline-2,3-dione (CAS 188784-45-4)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
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