Propafenone Impurity 34 CAS CATO-C4X-132234
| CAS No. | CATO-C4X-132234 |
| Molecular Formula | C21H27NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Propafenone Impurity 34 (C21H27NO3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Propafenone Impurity 34 (CAS CATO-C4X-132234, C21H27NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H27NO3 HCl |
| Molecular Weight | 377.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Propafenone Standards
- (R)-Propafenone (CAS 107381-31-7)
- (S)-Propafenone (CAS 107381-32-8)
- (R)-Propafenone HCl (CAS 107381-35-1)
- (S)-Propafenone HCl (CAS 107381-36-2)
- Propafenone-D7 Hydrochloride (CAS 1219799-06-0)
- Propafenone EP Impurity F (CAS 1329643-40-4)
- Propafenone Dimer Impurity-d10 (CAS 1346602-27-4)
- Propafenone EP Impurity G (CAS 1346603-80-2)
Recommended Standards
- Verapamil Impurity 44 (CAS CATO-C4X-177844)
- Dolutegravir Impurity 23 (CAS CATO-C4X-162023)
- SYH2051 Metabolite Impurity N67 (CAS CATO-C3D-262667)
- Regadenoson Impurity 38 (CAS CATO-C4X-198538)
- Ethyl 2-(2-cyanopyridin-3-yl)acetate (CAS 3423-45-8)
- diethyl (acetylamino)(2-phenylethyl)malonate (CAS 5463-92-3)
- 3-(4-(6-Aminocaproyloxy)phenyl)propionic Acid 4-[(6-Amino-1-oxohexyl)oxy]benzenepropanoic Acid 760127-60-4 (CAS 760127-60-4)
- Methyl 6-(isopropylamino)pyrazine-2-carboxylate (CAS 717851-89-3)
- 3-Hydroxy-1-phenyl-2-buten-1-one (CAS 33951-43-8)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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