Dolutegravir Impurity 23 CAS CATO-C4X-162023
| CAS No. | CATO-C4X-162023 |
| Molecular Formula | C21H15F5N2 |
| Molecular Weight | 390.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dolutegravir Impurity 23 (CAS CATO-C4X-162023) is a certified pharmaceutical impurity reference standard with the molecular formula C21H15F5N2 and a molecular weight of 390.35 g/mol.
Dolutegravir Impurity 23 (C21H15F5N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Dolutegravir Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H15F5N2 |
| Molecular Weight | 390.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dolutegravir Standards
- Dolutegravir Impurity 28 (CAS 1646862-09-0)
- Dolutegravir Impurity 5 (CAS 2244161-71-3)
- Dolutegravir Impurity 46 (CAS 2244245-34-7)
- Dolutegravir Impurity 50 (CAS CATO-C4X-162050)
- Dolutegravir Impurity 60 (CAS CATO-C4X-162060)
- Dolutegravir Impurity 8 (CAS 1863916-88-4)
- Dolutegravir Impurity 9 (CAS 1863916-87-3)
- Dolutegravir Impurity 31 (CAS CATO-C4X-162031)
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- Sildenafil Impurity 60 (CAS 503064-95-7)
- Ruilugoli lmpurity 129 (CAS CATO-C4X-2429129)
- Drotaverine Impurity 12 (CAS 92157-09-0)
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