N-Nitroso Nafamostat impurity 121 HCl CAS CATO-C4X-1332121
| CAS No. | CATO-C4X-1332121 |
| Molecular Formula | C19H16N6O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, N-Nitroso Nafamostat impurity 121 HCl (C19H16N6O3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 412.83 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, N-Nitroso Nafamostat impurity 121 HCl (CAS CATO-C4X-1332121, C19H16N6O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H16N6O3 HCl |
| Molecular Weight | 412.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related N Standards
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Recommended Standards
- Celecoxib Impurity 31 (CAS CATO-C4X-104331)
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- Tegoprazan Impurity 98 (CAS CATO-C4X-229798)
- 3,6-Dimethyl-2,3,4,9-tetrahydro-1H-carbazole (CAS 70473-88-0)
- 3-Amino-3-(pyridin-2-yl)propanoic acid (CAS 149251-81-0)
- 3-Chloro-5-methoxy-4-methylbenzoic acid (CAS 1429901-94-9)
- 3-(5-(Trifluoromethyl)pyridin-2-yl)thiazolidine (CAS 1707367-73-4)
- Tributyl(5’-hexyl-[2,2’-bithiophen]-5-yl)stannane (CAS 211737-37-0)
- 3-(Bis(methylthio)methylene)pentane-2,4-dione (CAS 15908-50-6)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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