Nafamostat Impurity 129 CAS CATO-C4X-1332129

Purity ≥97%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-1332129
Molecular FormulaC14H16O4
Molecular Weight248.27 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nafamostat Impurity 129 CAS CATO-C4X-1332129 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nafamostat Impurity 129.

As a process- or degradation-related impurity, Nafamostat Impurity 129 (CAS CATO-C4X-1332129, C14H16O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Nafamostat Impurity 129 (C14H16O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Nafamostat Impurity 129 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC14H16O4
Molecular Weight248.27 g/mol
AppearanceOff-white to pale yellow crystalline powder
Purity≥97%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present

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