N-Nitroso Nafamostat impurity 93 CAS CATO-C4X-133293
| CAS No. | CATO-C4X-133293 |
| Molecular Formula | C8H8N4O3 |
| Molecular Weight | 208.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 208.17 g/mol gives N-Nitroso Nafamostat impurity 93 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
N-Nitroso Nafamostat impurity 93 (CAS CATO-C4X-133293) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8N4O3 and a molecular weight of 208.17 g/mol.
N-Nitroso Nafamostat impurity 93 (C8H8N4O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8N4O3 |
| Molecular Weight | 208.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related N Standards
- N-Nitroso Nafamostat impurity 90 (CAS CATO-C4X-133290)
- N-Nitroso Benzocaine Impurity 1 (CAS 208176-48-1)
- N-Nitroso-N-methyl-DL-phenylalanine (CAS 41867-08-7)
- N-Nitroso-Cyclamate (CAS 70365-40-1)
- N-Nitroso Trimebutine Impurity 12 (CAS CATO-C4X-185812)
- N-Nitroso Memantine (CAS CATO-C4X-105848)
- N-Nitroso Paraxanthine (CAS CATO-C4X-133010)
- N-Nitroso Theophylline (CAS CATO-C4X-18235)
Recommended Standards
- D-Ascorbic Acid Impurity 19 (CAS 67776-07-2)
- N-Notroso Nafamostat impound 122 (CAS CATO-C4X-1332122)
- Ascorbic Acid EP Impurity D (CAS 3031-98-9)
- Prop-2-yn-1-yl 3,4,5-trihydroxybenzoate (CAS 343346-24-7)
- Aztreonam Impurity 92 (CAS 102586-36-7（free base）)
- Dimenhydrinate Impurity N4 (CAS 1797911-12-6)
- Lefamulinum Impurity 37 (CAS CATO-C4X-304737)
- 898791-55-4 7-(4-Hexylphenyl)-7-oxoheptanoic acid DTXSID60645431 (CAS 898791-55-4)
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- tert-Butyl 4-(5-benzoyl-4-methylpyridin-2-yl)piperazine-1-carboxylate (CAS 1355196-00-7)
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