Umeclidinium impurity 27 CAS CATO-C4X-133927
| CAS No. | CATO-C4X-133927 |
| Molecular Formula | C22H29NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Umeclidinium impurity 27 (CAS CATO-C4X-133927, C22H29NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Umeclidinium impurity 27 (C22H29NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Umeclidinium impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29NO2 HCl |
| Molecular Weight | 375.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Umeclidinium Standards
- Umeclidinium Bromide Impurity 25 (CAS 119102-52-2)
- Umeclidinium impurity 26 (CAS 1248400-28-3)
- Umeclidinium Impurity 1 (CAS 1509910-91-1)
- Umeclidinium impurity 22 (CAS 17229-17-3)
- Umeclidinium Impurity 15 (CAS 2230024-91-4(free base))
- Umeclidinium Impurity 19 (CAS 2253743-32-5)
- Umeclidinium Impurity 13 (CAS 2253743-36-9)
- Umeclidinium Impurity 11 (CAS 2253743-38-1)
Recommended Standards
- Methoxamine Impurity 12 (CAS CATO-C4X-202212)
- Trimebutine Impurity 14 (CAS CATO-C4X-185814)
- Thymidine Impurity 2 (CAS CATO-C4X-32972)
- 3-Methoxy-2-methylisonicotinaldehyde (CAS 1211589-76-2)
- 1-benzyl-4-methyl-4-phenylpyrrolidine-3-carboxylic acid hydrochloride (CAS 2044837-78-5)
- 1-(3,4-Dihydro-2H-pyran-2-yl)ethanone (CAS 3749-34-6)
- 2-Bromo-4-methyl-n-(thiazol-2-yl)benzenesulfonamide (CAS 1178482-11-5)
- 3-((2-Fluorobenzyl)thio)-6-(4-fluorophenyl)pyridazine (CAS 872695-02-8)
- N-[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]-2,2,2-trifluoro-acetamide (CAS 178261-42-2)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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