Ofloxacin EP Impurity E CAS CATO-C4X-137128
| CAS No. | CATO-C4X-137128 |
| Molecular Formula | C17H18FN3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 383.80 g/mol gives Ofloxacin EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ofloxacin EP Impurity E (CAS CATO-C4X-137128) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18FN3O4HCl and a molecular weight of 383.80 g/mol.
Based on its molecular formula C17H18FN3O4HCl, Ofloxacin EP Impurity E contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 383.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18FN3O4 HCl |
| Molecular Weight | 383.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Ofloxacin Standards
- Ofloxacin EP Impurity F(Levofloxacin Impurity 25) (CAS 104721-52-0)
- Ofloxacin Impurity 10 (CAS 107884-32-2)
- Ofloxacin EP Impurity A (CAS 110548-07-7)
- Ofloxacin D3 hydrochloride (CAS 1173021-78-7)
- Ofloxacin-D3 (CAS 1173147-91-5)
- Ofloxacin N-Oxide Acetic Acid Salt(Mixture of Isomer) (CAS 1216511-73-7)
- Ofloxacin-d8 (CAS 1219170-21-4)
- Ofloxacin EP Impurity B (CAS 123155-82-8)
Recommended Standards
- Riociguat Impurity 17 (CAS CATO-C4X-174917)
- Dacomitinib Impurity 35 (CAS CATO-C4X-208635)
- Milnacipran Impurity 5 (CAS 1932365-99-5)
- 4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-amine (CAS 152491-80-0)
- 6-Benzylamino-2-Methyl-Heptan-2-Ol (CAS 71173-00-7)
- 7-Chloro-5-methyl-2H-1,4-benzothiazin-3(4H)-one (CAS 15182-83-9)
- 6-Chloro-2H-[1,3]dioxolo[4,5-b]pyridine (CAS 692057-07-1)
- 6-(morpholin-4-yl)pyrimidine-4-carboxylic acid (CAS 933759-51-4)
- 5-{2-[methyl(phenyl)amino]-2-oxoethyl}-4-oxo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxylic acid (CAS 1443978-32-2)
- Fibrinogen Related Peptide (CAS 80755-86-8)
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