Ofloxacin EP Impurity F(Levofloxacin Impurity 25) CAS 104721-52-0
| CAS No. | 104721-52-0 |
| Molecular Formula | C18H20FN3O5 |
| Molecular Weight | 377.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ofloxacin EP Impurity F(Levofloxacin Impurity 25) (C18H20FN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 377.37 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Ofloxacin EP Impurity F(Levofloxacin Impurity 25) (CAS 104721-52-0), a pharmacopoeial impurity reference standard (molecular formula C18H20FN3O5, MW 377.37 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H20FN3O5 |
| Molecular Weight | 377.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ofloxacin Standards
Recommended Standards
- Avibactam Impurity 114 (CAS CATO-C4X-1348114)
- Levofloxacin EP Impurity C(Levofloxacin N-Oxide) (CAS 117678-38-3)
- Isaaconazole lmpurity 94 (CAS CATO-C4X-123694)
- Relebactam Impurity 41 (CAS CATO-C4X-214441)
- Loxoprofen impurity 106 (CAS CATO-C4X-1488106)
- Fluticasone Propionate EP Impurity D (CAS 73205-13-7)
- Lafutidine Impurity 8 (CAS CATO-C4X-14768)
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- methyl 4-bromo-2,2-dimethyl-3-oxopentanoate (CAS 1392512-58-1)
- Ezetimibe Impurity 90 (CAS CATO-C4X-109890)
- tert-Butyl(4-chlorophenoxy)dimethylsilane (CAS 126644-72-2)
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