Rivastigmine Hydrogen Tartrate EP Impurity E HCl CAS CATO-C4X-138423
| CAS No. | CATO-C4X-138423 |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 272.77 g/mol gives Rivastigmine Hydrogen Tartrate EP Impurity E HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Rivastigmine Hydrogen Tartrate EP Impurity E HCl (CAS CATO-C4X-138423, C13H20N2O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rivastigmine Hydrogen Tartrate EP Impurity E HCl (C13H20N2O2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 272.77 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20N2O2 HCl |
| Molecular Weight | 272.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Rivastigmine Standards
- Rivastigmine Impurity 10 (CAS 105601-04-5)
- rac-Rivastigmine (CAS 105601-20-5)
- Rivastigmine RC 5 (CAS 1070660-34-2)
- Rivastigmine Benzyl Impurity (CAS 1111083-50-1)
- Rivastigmine-d3 (CAS 1133229-21-6)
- Rivastigmine-d5 (CAS 1133229-22-7)
- Rivastigmine Impurity 26 (CAS 1213234-40-2)
- Rivastigmine EP Impurity B (CAS 1230021-28-9)
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