Loratadine Impurity 48 CAS CATO-C4X-142648
| CAS No. | CATO-C4X-142648 |
| Molecular Formula | C30H40ClN5O |
| Molecular Weight | 522.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Loratadine Impurity 48 (CAS CATO-C4X-142648, C30H40ClN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Loratadine Impurity 48 (C30H40ClN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H40ClN5O |
| Molecular Weight | 522.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Loratadine Standards
- Loratadine Impurity 46 (CAS CATO-C4X-142646)
- Loratadine Impurity 60 (CAS CATO-C4X-142660)
- Loratadine Impurity 58 (CAS CATO-C4X-142658)
- Loratadine Impurity 42 (CAS CATO-C4X-142642)
- Loratadine Impurity 44 (CAS CATO-C4X-142644)
- Loratadine Impurity 64 (CAS CATO-C4X-142664)
- Loratadine Impurity 54 (CAS CATO-C4X-142654)
- Loratadine Impurity 56 (CAS CATO-C4X-142656)
Recommended Standards
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