Venlafaxine Impurity 77 CAS CATO-C4X-143477
| CAS No. | CATO-C4X-143477 |
| Molecular Formula | C18H29NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 327.89 g/mol gives Venlafaxine Impurity 77 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Venlafaxine Impurity 77 (CAS CATO-C4X-143477, C18H29NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Venlafaxine Impurity 77 (C18H29NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H29NO2 HCl |
| Molecular Weight | 327.89 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Venlafaxine Standards
- Venlafaxine Impurity 58 (CAS 1000377-27-4)
- Venlafaxine Impurity 31 (CAS 1020719-35-0)
- Venlafaxine Impurity 15 (CAS 1021933-95-8)
- Venlafaxine Impurity 33 (CAS 1062607-49-1)
- Venlafaxine Impurity 36 (CAS 1062609-99-7)
- Venlafaxine EP Impurity G (CAS 1076199-92-2)
- Venlafaxine N-Oxide (CAS 1094598-37-4)
- Venlafaxine Impurity 18 (CAS 1168135-16-7)
Recommended Standards
- Bilastine impurity 91 (CAS 2245209-60-1)
- Polaprezinc Impurity 5 HCl (CAS CATO-C4X-182117)
- Relebactam Impurity 27 (CAS CATO-C4X-214427)
- 1-Methyl-4-((1-methylpyrrolidin-2-yl)methyl)piperazine (CAS 100535-85-1)
- tert-Butyl 2-oxotetrahydropyrimidine-1(2H)-carboxylate (CAS 131056-76-3)
- 3-(N-phenylsulfamoyl)benzoic acid (CAS 1576-45-0)
- N-(5-Bromo-2-chloropyrimidin-4-yl)acetamide (CAS 934236-39-2)
- 2-(5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine-6-carbonyl)-4H-chromen-4-one (CAS 1797183-67-5)
- n-(Cyclopropylmethyl)-2-hydroxy-5-methylbenzamide (CAS 1019405-20-9)
- Vancomycin Hexapeptide (CAS 115236-65-2)
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