Deferasirox Impurity 1 CAS CATO-C4X-14381
| CAS No. | CATO-C4X-14381 |
| Molecular Formula | C22H15NO3 |
| Molecular Weight | 341.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Deferasirox Impurity 1 (CAS CATO-C4X-14381, C22H15NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Deferasirox Impurity 1 (C22H15NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Deferasirox Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H15NO3 |
| Molecular Weight | 341.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Deferasirox Standards
- Deferasirox Impurity 2 (CAS CATO-C4X-14382)
- Deferasirox Impurity 25 (CAS CATO-C4X-143825)
- Deferasirox (CAS 201530-41-8)
- Deferasirox EP Impurity C (CAS 201530-78-1)
- Deferasirox EP Impurity D (CAS 2254105-61-6)
- Deferasirox-d4 (CAS 1133425-75-8)
- Deferasirox Impurity 22 (CAS CATO-C4X-143822)
- Deferasirox Impurity 9 (CAS 1266741-05-2)
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