Naphazoline Impurity 8 CAS CATO-C4X-14408
| CAS No. | CATO-C4X-14408 |
| Molecular Formula | C13H13NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Naphazoline Impurity 8 (CAS CATO-C4X-14408), a pharmacopoeial impurity reference standard (molecular formula C13H13NOHCl, MW 235.71 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Naphazoline Impurity 8 (C13H13NOHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H13NO HCl |
| Molecular Weight | 235.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Naphazoline Standards
- Naphazoline Impurity 2 (CAS 1019-21-2)
- Naphazoline EP Impurity C (CAS 132-75-2)
- Naphazoline Impurity 1 (CAS 17518-47-7)
- Naphazoline EP Impurity D (CAS 22126-67-6)
- Naphazoline EP Impurity A (CAS 36321-43-4)
- Naphazoline Impurity 6 (CAS 36660-46-5)
- Naphazoline Nitrate (CAS 5144-52-5)
- Naphazoline hydrochloride (CAS 550-99-2)
Recommended Standards
- Atrasentan Impurity 127 (CAS 1063835-98-2)
- Cariprazine Impurity 50 (CAS CATO-C4X-240850)
- Sertraline EP Impurity G HCl (CAS 79645-15-1)
- 2-(2-Bromobenzo[d]thiazol-6-yl)acetonitrile (CAS 924287-70-7)
- 2-(2-Bromophenyl)-1,2-thiazinane 1,1-dioxide (CAS 1081316-85-9)
- (1r)-1-(Naphthalen-2-yl)ethane-1,2-diol (CAS 49801-14-1)
- Methyl 3-(5-isopropyl-3-methylisoxazole-4-carboxamido)propanoate (CAS 1209747-76-1)
- 3,6-dichloro-1$l^{6},2-benzothiazole-1,1-dione (CAS 15864-53-6)
- 2-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]benzoic acid (CAS 950029-19-3)
- Polymyxin B nonapeptide (CAS 86408-36-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com