Propofol Impuirity 45 CAS CATO-C4X-147345
| CAS No. | CATO-C4X-147345 |
| Molecular Formula | C12H17Na2O4P |
| Molecular Weight | 302.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Propofol Impuirity 45 (CAS CATO-C4X-147345, C12H17Na2O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H17Na2O4P, Propofol Impuirity 45 contains a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 302.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H17Na2O4P |
| Molecular Weight | 302.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Propofol Standards
- Propofol Impurity 51 (CAS CATO-C4X-147351)
- Propofol impurity 63 (CAS 110398-11-3)
- Propofol Impurity 43 (CAS CATO-C4X-147343)
- Propofol Impurity 21 (CAS 83237-15-4)
- Propofol Impurity 49 (CAS CATO-C4X-147349)
- Propofol Impurity 53 (CAS CATO-C4X-147353)
- Propofol Impurity 18 (CAS CATO-C4X-147318)
- Propofol Impurity 28 (CAS 40388-51-0)
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