Itraconazole Methoxy ButyItriazolone Impurity CAS CATO-C4X-149710
| CAS No. | CATO-C4X-149710 |
| Molecular Formula | C23H29N5O2 |
| Molecular Weight | 407.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Itraconazole Methoxy ButyItriazolone Impurity (CAS CATO-C4X-149710), a pharmacopoeial impurity reference standard (molecular formula C23H29N5O2, MW 407.51 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Itraconazole Methoxy ButyItriazolone Impurity (C23H29N5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H29N5O2 |
| Molecular Weight | 407.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Itraconazole Standards
- Itraconazole EP Impurity A (CAS 252964-68-4)
- Itraconazole Impurity 26（Relative stereochemistry） (CAS 67914-86-7)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole Impurity 65 (CAS 88710-27-4)
- Itraconazole Impurity 71 (CAS CATO-C4X-149771)
- Itraconazole Impurity 80 (CAS CATO-C4X-149780)
- Itraconazole Impurity 26 (CAS 89848-20-4)
- Itraconazole Impurity 41 (CAS 106461-41-0)
Recommended Standards
- Posaconazole Impurity 121 (CAS 212632-01-4)
- N-[(Thiophen-2-yl)methyl]-2-{4-[4-(thiophen-2-yl)pyrimidin-2-yl]phenoxy}acetamide (CAS 477888-55-4)
- Lasmiditan Impurity 26 (CAS CATO-C4X-247826)
- N-(4-Methyl-2-(morpholinosulfonyl)phenyl)-2-(methylthio)nicotinamide (CAS 380570-15-0)
- Furosemide Impurity 54 (CAS 33069-75-9)
- Ibuprofen Impurity 136 (CAS CATO-C4X-1082136)
- Ceftriaxone Impurity 25 (CAS CATO-C4X-116325)
- Morpholino(p-tolyl)methanone (CAS 63833-44-3)
- (3R)-4-(4-cyanophenyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid (3R)-4-(4-cyanophenyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid (3R)-4-(4-cyanophenyl)-3-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]butanoic acid 269726-87-6 Fmoc-(R)-3-Amino-4-(4-cyanophenyl)-butyric acid (CAS 269726-87-6)
- 1-((1-Methyl-1h-imidazol-2-yl)thio)butan-2-amine (CAS 752970-20-0)
- 6-(1H-Imidazol-4-yl)pyrimidin-4-amine (CAS 840529-38-6)
- 4-(chloromethyl)-2-methyl-thiazole (CAS 39238-07-8)
- N-(3-chloro-4-(pyrimidin-2-yloxy)phenyl)-4-methylbenzamide (CAS 338413-26-6)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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