Itraconazole Impurity 65 CAS 88710-27-4
| CAS No. | 88710-27-4 |
| Molecular Formula | C19H18Cl2N4O3 |
| Molecular Weight | 421.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Itraconazole Impurity 65.
CATO supplies Itraconazole Impurity 65 (CAS 88710-27-4), a pharmacopoeial impurity reference standard (molecular formula C19H18Cl2N4O3, MW 421.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Itraconazole Impurity 65 (C19H18Cl2N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Itraconazole Impurity 65 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H18Cl2N4O3 |
| Molecular Weight | 421.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >85% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Itraconazole Standards
- Itraconazole Impurity 71 (CAS CATO-C4X-149771)
- Itraconazole Impurity 80 (CAS CATO-C4X-149780)
- Itraconazole Impurity 12 (CAS 67914-84-5)
- Itraconazole Impurity 26（Relative stereochemistry） (CAS 67914-86-7)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole Methoxy ButyItriazolone Impurity (CAS CATO-C4X-149710)
- Itraconazole EP Impurity A (CAS 252964-68-4)
- Itraconazole Impurity 26 (CAS 89848-20-4)
Recommended Standards
- N-(4-Iodophenyl)-2-(4-phenylpiperazin-1-yl)acetamide (CAS 329779-34-2)
- 1-(7-(Benzhydryloxy)-4-bromobenzofuran-2-yl)ethanone (CAS 826992-35-2)
- 2-((N-(2,4-dichloro-5-methoxyphenyl)-4-fluorophenyl)sulfonamido)-N-methylacetamide (CAS 338967-33-2)
- 2-(6-Bromo-2,4-diphenylquinazolin-3(4h)-yl)acetic acid (CAS 313650-47-4)
- Apalutamide Impurity 106 (CAS CATO-C4X-2749106)
- Riociguat Impurity 9 (CAS 956010-88-1)
- Halcinonide Impurity 13 (CAS CATO-C4X-279513)
- Hesperetin 7-O-glucoside (CAS 31712-49-9)
- Lenvatinib Impurity 15 (CAS 796848-80-1)
- D-Threose (CAS 95-43-2)
- 1-(tert-Butyl) 4-ethyl (2R)-2-methyl-5-oxopiperidine-1,4-dicarboxylate (CAS 2768212-81-1)
- (2E,2'E)-4,4'-(naphthalene-1,5-diylbis(azanediyl))bis(4-oxobut-2-enoic acid) (CAS 293323-14-5)
- [(2-methylbut-3-yn-2-yl)sulfamoyl]amine (CAS 1566709-32-7)
- Liraglutide(8-31)TFA Salt (CAS CATO-C4X-19922)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com