Amorolfine Impurity 58 CAS CATO-C4X-154258
| CAS No. | CATO-C4X-154258 |
| Molecular Formula | C11H14I2 |
| Molecular Weight | 400.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Amorolfine Impurity 58 is closely related to iodine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Amorolfine Impurity 58 (CAS CATO-C4X-154258, C11H14I2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Amorolfine Impurity 58 (C11H14I2) is characterized by iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14I2 |
| Molecular Weight | 400.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
Related Amorolfine Standards
- Amorolfine Impurity 63 (CAS CATO-C4X-154263)
- Amorolfine Impurity 36 (CAS CATO-C4X-154236)
- Amorolfine Impurity 16 (CAS CATO-C4X-154216)
- Amorolfine EP Impurity B (CAS 142347-84-0)
- Amorolfine Impurity 85 (CAS 2835559-25-4)
- rac-Amorolfine Impurity 18 (Mixture of Diastereomers) (CAS CATO-C4X-154218)
- Amorolfine EP impurity M (CAS CATO-C4X-154227)
- Amorolfine impurity 73 (CAS 78613-39-5)
Recommended Standards
- NSC 617145 (CAS 203115-63-3)
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