Ticagrelor Impurity 44 CAS 145783-15-9
| CAS No. | 145783-15-9 |
| Molecular Formula | C7H9Cl2N3S |
| Molecular Weight | 238.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ticagrelor Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ticagrelor Impurity 44 (CAS 145783-15-9, C7H9Cl2N3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Ticagrelor Impurity 44 (C7H9Cl2N3S) contains a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 238.14 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H9Cl2N3S |
| Molecular Weight | 238.14 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor impurity 95 (CAS CATO-C4X-109395)
- Ticagrelor Impurity 39 (CAS 1431867-40-1)
- Ticagrelor Impurity 61 (CAS CATO-C4X-109361)
- Ticagrelor Impurity 158 (CAS 1402150-27-9)
- Ticagrelor Impurity 43 (CAS 145783-13-7)
- Ticagrelor Impurity 62 (CAS CATO-C4X-109362)
- Ticagrelor Impurity 100 (CAS 39856-08-1)
- Ticagrelor impurity 98 (CAS 1548397-10-9)
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