Diclofenac impurity 8 CAS CATO-C4X-16148
| CAS No. | CATO-C4X-16148 |
| Molecular Formula | C14H11Cl2NO |
| Molecular Weight | 280.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Diclofenac impurity 8 (CAS CATO-C4X-16148), a pharmacopoeial impurity reference standard (molecular formula C14H11Cl2NO, MW 280.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Diclofenac impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 280.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Diclofenac impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11Cl2NO |
| Molecular Weight | 280.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac impurity N2 (CAS 84803-53-2)
- Diclofenac sodium Impurity 58 (CAS 848060-64-0)
- Diclofenac acid Impurity 59 (CAS 304884-75-1)
- Diclofenac Sodium Impurity 35 (CAS 13625-57-5)
- Diclofenac EP Impurity A (CAS 15362-40-0)
- Diclofenac Sodium Impurity 34 (CAS 123790-84-1)
- Diclofenac Impurity 20 (CAS 15362-44-4)
- Diclofenac Impurity 11 (CAS 51550-51-7)
Recommended Standards
- (5-Chloro-2-(methylamino)phenyl)(2-chlorophenyl)methanone (CAS 5621-86-3)
- 1,3-Bis(4-chlorophenyl)guanidine (CAS 89869-39-6)
- 2-(4-Bromophenyl)-2-(piperazin-1-yl)acetonitrile (CAS 1000406-20-1)
- 401582-14-7 2-Chloro-N-(2-chlorophenyl)-2-phenylacetamide MFCD00439031 (CAS 401582-14-7)
- Baricitinib Impurity 101 (CAS CATO-C4X-2260101)
- Tadalafil Impurity 37 (CAS 171489-59-1)
- Teneligliptin Impurity 16 (CAS CATO-C4X-176016)
- Z-Asu(OtBu)-OH · DCHA (CAS 49645-27-4)
- 4-Chloro-2-methylbenzyl alcohol (CAS 129716-11-6)
- (3AS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ol (CAS 1807882-35-4)
- (Ethoxycarbonylmethyl)triphenylphosphine chloride (CAS 17577-28-5)
- 1-(2-Methyl-3-nitrobenzyl)piperazine (CAS 1156644-75-5)
- Policresulen Impurity 16 (CAS 17011-26-6)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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