Entacapone impurity 54 CAS CATO-C4X-162954
| CAS No. | CATO-C4X-162954 |
| Molecular Formula | C16H12Cl2N4O7 |
| Molecular Weight | 443.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 443.20 g/mol gives Entacapone impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Entacapone impurity 54 (CAS CATO-C4X-162954), a pharmacopoeial impurity reference standard (molecular formula C16H12Cl2N4O7, MW 443.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Entacapone impurity 54 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 443.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2N4O7 |
| Molecular Weight | 443.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Entacapone Standards
- Entacapone Impurity 35 (CAS CATO-C4X-162935)
- Entacapone Impurity 5（Mixture of chiral isomers） (CAS CATO-C4X-16295)
- Entacapone impurity 43 (CAS CATO-C4X-162943)
- Entacapone impurity 41 (CAS CATO-C4X-162941)
- Entacapone 3-b-D-glucuronide (CAS 158069-75-1)
- Entacapone impurity 46 (CAS CATO-C4X-162946)
- Entacapone impurity 47 (CAS 1402714-31-1)
- Entacapone impurity 49 (CAS CATO-C4X-162949)
Recommended Standards
- Dihydroergotamine Mesylate Impurity 1 (CAS 81149-12-4)
- Guanosine 5'-Diphosphate (CAS 146-91-8)
- Dichloro-oxacalix[2]arene[2]triazine, 95% (CAS 819065-56-0)
- Opicapone Impurity 73 (CAS CATO-C4X-240473)
- Drotaverine Impurity 29 (CAS CATO-C4X-243529)
- Canagliflozin Impurity 41 (CAS CATO-C4X-112341)
- Afatinib Impurity 33 (CAS CATO-C4X-100633)
- N-(1-benzylpyrrolidin-3-yl)-2,2,2-trifluoroacetamide (CAS 115445-23-3)
- 2-Bromo-4'-fluoro-1,1'-biphenyl (CAS 89346-54-3)
- Almotriptan HCl (CAS 154323-46-3)
- H-D-Cys(Bzl)-OH (CAS 23032-53-3)
- tert-Butyl (3S,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride (CAS 154633-74-6)
- 1-Cyclopropyl-1-(4-isopropylphenyl)ethan-1-ol (CAS 1342369-21-4)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com