Entacapone impurity 43 CAS CATO-C4X-162943
| CAS No. | CATO-C4X-162943 |
| Molecular Formula | C15H12Cl2N4O7 |
| Molecular Weight | 431.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Entacapone impurity 43 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Entacapone impurity 43 (CAS CATO-C4X-162943) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12Cl2N4O7 and a molecular weight of 431.18 g/mol.
Structurally, Entacapone impurity 43 (C15H12Cl2N4O7) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 431.18 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Entacapone impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12Cl2N4O7 |
| Molecular Weight | 431.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Entacapone Standards
- Entacapone impurity 41 (CAS CATO-C4X-162941)
- Entacapone impurity 54 (CAS CATO-C4X-162954)
- Entacapone Impurity 35 (CAS CATO-C4X-162935)
- Entacapone Impurity 5（Mixture of chiral isomers） (CAS CATO-C4X-16295)
- Entacapone impurity 46 (CAS CATO-C4X-162946)
- Entacapone impurity 47 (CAS 1402714-31-1)
- Entacapone impurity 49 (CAS CATO-C4X-162949)
- Entacapone impurity 51 (CAS CATO-C4X-162951)
Recommended Standards
- Ethyl 6-(2-ethoxy-2-oxoacetyl)-7-iodo-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylate (CAS 1423742-69-1)
- Opicapone Impurity 47 (CAS CATO-C4X-240447)
- 2,2,3,3,4,4-Hexafluoro-5-oxo-5-((3-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)pentanoic acid (CAS 1024184-05-1)
- AS-703026 (CAS 1236699-92-5)
- Perospirone Impurity 58 (CAS 151504-04-0)
- Brivaracetam Impurity 149 (CAS CATO-C4X-2007149)
- Tranexamic Impurity 21 (CAS 195370-52-6)
- Bisamide (CAS 123-26-2)
- 2-Benzyl-6-chloropyridine (CAS 74714-04-8)
- tert-Butyl 3-(2,2,2-Trifluoro-1-hydroxyethyl)piperidine-1-carboxylate (CAS 1283718-04-6)
- 1,4-oxazepane-5-carboxylic acid (CAS 1779647-41-4)
- Carbazochrome Impurity 6 (CAS CATO-C4X-22916)
- 5-(4-Fluorophenyl)-2-methyl-2H-1,2,6-thiadiazine-3-carboxylic acid 1,1-dioxide (CAS 899539-96-9)
- Calcitonin N-Terminal Flanking Peptide (human) (CAS 118277-01-3)
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