Ipratropium Impurity 43 CAS CATO-C4X-166543
| CAS No. | CATO-C4X-166543 |
| Molecular Formula | C20H30NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ipratropium Impurity 43 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ipratropium Impurity 43 (CAS CATO-C4X-166543, C20H30NO3Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ipratropium Impurity 43 (C20H30NO3Br) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H30NO3 Br |
| Molecular Weight | 412.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Ipratropium Standards
- Ipratropium Impurity 24 (Mixture of Isomers) (CAS 17812-46-3)
- Ipratropium Impurity 17 (CAS 17838-69-6)
- (S)-Ipratropium Bromide EP Impurity E Formate (CAS 183626-76-8)
- Ipratropium Bromide EP Impurity E (CAS 22235-81-0)
- Ipratropium Bromide (CAS 22254-24-6)
- Ipratropium Impurity 30 (CAS 259092-15-4)
- Ipratropium Bromide Impurity 33 (CAS 2784-21-6)
- Ipratropium Impurity 31 (CAS 3423-25-4)
Recommended Standards
- Gatifloxacin Impurity 32 (CAS CATO-C4X-125332)
- Timolol Impurity 23 (CAS CATO-C4X-149623)
- Levocetirizine Impurity 9 (CAS CATO-C4X-10839)
- 3,4-Dimethyl-2-hexanone (CAS 19550-10-8)
- 2-Bromo-1,3-dimethyl-4-nitrobenzene, 97% (CAS 60956-25-4)
- 5-Cyclopropoxy-N-methyl-6-(methylthio)pyridin-3-amine (CAS 1243376-31-9)
- N-Isopropyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxamide (CAS 1082328-56-0)
- (S)-1-(3,5-difluorophenyl)-2,2-dimethylpropan-1-amine (CAS 1388128-18-4)
- 3-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 2866352-08-9)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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