LCZ-696 Impurity 54 CAS CATO-C4X-169654
| CAS No. | CATO-C4X-169654 |
| Molecular Formula | C15H15NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, LCZ-696 Impurity 54 (CAS CATO-C4X-169654, C15H15NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H15NOHCl, LCZ-696 Impurity 54 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 261.75 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H15NO HCl |
| Molecular Weight | 261.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Gadoteridol impurity 38 (CAS CATO-C4X-225738)
- Levosimendan Impurity 1 (CAS 252638-01-0)
- Metformin EP Impurity C (CAS 1985-46-2)
- 1-(3,4-Difluorophenyl)-4-methoxy-6-oxo-1,6-dihydropyridazine-3-carboxylic acid (CAS 1616500-63-0)
- N1-(Thiazol-4-ylmethyl)ethane-1,2-diamine (CAS 105954-28-7)
- 1,4-phenylenediamine-d<SUB>8</SUB> (CAS 153200-73-8)
- N'-phenylcinnamohydrazide (CAS 129200-93-7)
- Crisaborole Impurity 26 (CAS CATO-C4X-202126)
- 4-(Tert-butyl)cyclohexan-1-one O-(3,4-dichlorobenzoyl) oxime (CAS 439107-93-4)
- Semaglutide238 (CAS CATO-C4X-2226238)
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