LCZ-696 Impurity 77 CAS CATO-C4X-169677
| CAS No. | CATO-C4X-169677 |
| Molecular Formula | C18H19NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies LCZ-696 Impurity 77 (CAS CATO-C4X-169677), a pharmacopoeial impurity reference standard (molecular formula C18H19NO2C2HF3O2, MW 395.38 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of LCZ-696 Impurity 77 (C18H19NO2C2HF3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), LCZ-696 Impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H19NO2 C2HF3O2 |
| Molecular Weight | 395.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
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- 1-(2,5-Dichlorophenyl)guanidine (CAS 41213-70-1)
- 4-(5-Bromofuran-2-yl)-2,6-dichloropyrimidine (CAS 908141-98-0)
- 2-(3,5-dimethylphenyl)ethan-1-amine (CAS 76935-61-0)
- 7-iodo-4-methoxy-indan-1-one (CAS 436091-91-7)
- 1-(3-Fluoro-4-(3-methylpiperidin-1-yl)phenyl)ethan-1-one (CAS 1019547-53-5)
- n-[3-(4-tert-butylphenyl)-1-phenyl-1h-pyrazol-5-yl]-2-chloroacetamide (CAS 882227-09-0)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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