Minoxidil Impurity 66 CAS CATO-C4X-170066
| CAS No. | CATO-C4X-170066 |
| Molecular Formula | C4H5ClN4O2 |
| Molecular Weight | 176.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Minoxidil Impurity 66 (C4H5ClN4O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Minoxidil Impurity 66 (CAS CATO-C4X-170066) is a certified pharmaceutical impurity reference standard with the molecular formula C4H5ClN4O2 and a molecular weight of 176.56 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Minoxidil Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5ClN4O2 |
| Molecular Weight | 176.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Minoxidil Standards
- Minoxidil Impurity 22 (CAS 56488-00-7)
- Minoxidil Impurity 68 (CAS CATO-C4X-170068)
- Minoxidil Impurity 33 (CAS 114562-80-0)
- Minoxidil Impurity 21 (CAS 128304-91-6)
- Minoxidil Impurity 67 (CAS CATO-C4X-170067)
- Minoxidil Impurity 53 (CAS CATO-C4X-170053)
- Minoxidil Impurity 59 (CAS CATO-C4X-170059)
- Minoxidil Impurity 24 (CAS CATO-C4X-170024)
Recommended Standards
- 1-Imidazolidinecarbonyl chloride, 3-methyl-2,4-dioxo- (CAS 68471-52-3)
- 3-Chloro-5-fluoro-4-methoxyphenol (CAS 1017777-55-7)
- (2,5-Dioxoimidazolidin-4-yl)acetyl chloride (CAS 51876-11-0)
- 2-Chloro-6-fluoro-3-methoxyphenol (CAS 1017777-60-4)
- Lorazepam Impurity 20 (CAS CATO-C4X-104120)
- Etomidate impurity 56 (CAS 83898-12-8)
- Nilotinib Impurity 13 (CAS CATO-C4X-125613)
- 3-(3-Methylthiophen-2-yl)propanoic acid (CAS 25468-85-3)
- 6-chloro-1,2-dihydroquinazolin-2-one (CAS 60610-12-0)
- (S)-Ethyl 2-((tert-butoxycarbonyl)amino)pentanoate (CAS 1187550-23-7)
- Cholic Acid Impurity 49 (CAS 691519-36-4)
- 2-(Benzyloxy)-6-bromoquinoline-5-carbonitrile (CAS 2243972-67-8)
- Methyl 3-((tert-butoxycarbonyl)amino)-3-(2,4-difluorophenyl)propanoate (CAS 1260666-87-2)
- Neuropeptide Y, human (CAS 98264-90-5)
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