Pemetrexed Impurity 66 CAS CATO-C4X-172666
| CAS No. | CATO-C4X-172666 |
| Molecular Formula | C15H16N6O2 |
| Molecular Weight | 312.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pemetrexed Impurity 66 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Pemetrexed Impurity 66 (CAS CATO-C4X-172666) is a certified pharmaceutical impurity reference standard with the molecular formula C15H16N6O2 and a molecular weight of 312.33 g/mol.
Pemetrexed Impurity 66 (C15H16N6O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Pemetrexed Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H16N6O2 |
| Molecular Weight | 312.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Pemetrexed Standards
- Pemetrexed Impurity 17 (CAS CATO-C4X-172617)
- Pemetrexed Impurity 16 (CAS CATO-C4X-172616)
- Pemetrexed Impurity 33 (CAS 193265-47-3)
- Pemetrexed Impurity N24 (CAS 1797982-74-1)
- Pemetrexed Impurity 24 (CAS 869791-47-9)
- Pemetrexed Impurity 49 (CAS CATO-C4X-172649)
- Pemetrexed Impurity 50 (CAS CATO-C4X-172650)
- Pemetrexed Impurity 7 (CAS 137281-39-1)
Recommended Standards
- Rilpivirine Impurity 4 (CAS 1629023-90-0)
- Rimegepant Impurity 151 (CAS CATO-C4X-2487151)
- Tris(4-pyridyl)-s-triazine (CAS 42333-78-8)
- Rimegepant Impurity 58 (CAS 1373116-06-3)
- Tolvaptan Impurity 4 (CAS 1133419-00-7)
- Teneligliptin impurity 33 (CAS CATO-C4X-176033)
- Peramivir Impurity 82 (CAS CATO-C4X-183382)
- 1-(3,5-Dichloro-2-fluoropyridin-4-yl)ethan-1-ol (CAS 2887531-07-7)
- Fmoc-Glu-2-phenylisopropyl ester (CAS 207305-97-3)
- 1355334-57-4 2-[2,5-Bis(trifluoromethyl)phenyl]-ethanimidamide hydrochloride (CAS 1355334-57-4)
- Ceftolozane Impurity N2 (CAS 116856-12-3)
- 2-(((5-(O-tolylcarbamoyl)-1,3,4-thiadiazol-2-yl)methyl)thio)acetic acid (CAS 1142209-76-4)
- N-((3aR,5s,6aS)-octahydrocyclopenta[c]pyrrol-5-yl)acetamide (CAS 1326805-42-8)
- Semaglutide impurity 86 (CAS CATO-C4X-152686)
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