Riociguat Impurity 12 CAS CATO-C4X-174912
| CAS No. | CATO-C4X-174912 |
| Molecular Formula | C21H20FN7O2 |
| Molecular Weight | 421.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Riociguat Impurity 12 (CAS CATO-C4X-174912) is a certified pharmaceutical impurity reference standard with the molecular formula C21H20FN7O2 and a molecular weight of 421.43 g/mol.
Riociguat Impurity 12 (C21H20FN7O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Riociguat Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H20FN7O2 |
| Molecular Weight | 421.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Riociguat Standards
- Riociguat Impurity 11 (CAS CATO-C4X-174911)
- Riociguat (CAS 625115-55-1)
- Riociguat Impurity 15 (CAS CATO-C4X-174915)
- Riociguat Impurity 22 (CAS CATO-C4X-174922)
- Riociguat Impurity 38 (CAS CATO-C4X-174938)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- Riociguat-13C-d3 (CAS 1304478-43-0)
- Riociguat Impurity 17 (CAS CATO-C4X-174917)
Recommended Standards
- Cyclosulfamuron (CAS 136849-15-5)
- Adenosine Impurity 20 (CAS 42776-78-3)
- Diethyl(troc-amino)bromomethylphosphonate (CAS 108217-08-9)
- Adenosine 5’-Tosylate (CAS 5135-30-8)
- Iguratimod Impurity 141 (CAS CATO-C4X-1826141)
- Peridine Impurity 21 (CAS CATO-C4X-239921)
- Darolutamide Impurity 1 (CAS CATO-C4X-31061)
- (5-Phenylfuran-2-yl)boronic acid (CAS 1628569-51-6)
- Ethyl 6-hydrazinylnicotinate (CAS 70022-06-9)
- 5-Methoxy-7-methylbenzofuran (CAS 1388059-31-1)
- 2-Amino-6-bromo-5-chloronicotinic acid (CAS 2230875-16-6)
- 2-(Isopropylamino)-6-(3-nitrophenyl)quinazolin-7-ol (CAS 914395-73-6)
- tert-Butyl hexahydro-1H-pyrido[1,2-a]pyrazine-2(6H)-carboxylate (CAS 1493766-60-1)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com