Tiotropium Bromide EP Impurity K CAS CATO-C4X-176411
| CAS No. | CATO-C4X-176411 |
| Molecular Formula | C19H19NO5S2 |
| Molecular Weight | 405.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tiotropium Bromide EP Impurity K (CAS CATO-C4X-176411, C19H19NO5S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tiotropium Bromide EP Impurity K (C19H19NO5S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 405.49 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tiotropium Bromide EP Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19NO5S2 |
| Molecular Weight | 405.49 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Tiotropium Standards
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium Bromide Impurity 20 (CAS 1459721-06-2)
- Tiotropium impurity 43 (CAS CATO-C4X-176443)
- Tiotropium EP Impurity D (CAS 136310-66-2)
- Tiotropium impurity 49 (CAS CATO-C4X-176449)
- Tiotropium impurity 45 (CAS 535995-21-2)
- Tiotropium impurity 42 (CAS 2512209-13-9)
- Tiotropium impurity 50 (CAS CATO-C4X-176450)
Recommended Standards
- Lisinopril EP Impurity E (CAS 85955-59-5)
- Pyridoxine impurity 86 (CAS CATO-C4X-187786)
- Lisinopril (CAS 76547-98-3)
- Selexipag Impurity 63 (CAS CATO-C4X-196163)
- Lasmiditan Impurity 23 (CAS CATO-C4X-247823)
- Diclofenac sodium Impurity 39 (CAS CATO-C4X-105139)
- Indacaterol Impurity 32 (CAS CATO-C4X-150032)
- Z-HoMet-OH (CAS 2044704-55-2)
- (S)-4-Amino-4-(5-bromo-2-fluorophenyl)-2,2-difluoropentan-1-ol (CAS 1956437-49-2)
- N-(4,6-Dimethylpyrimidin-2-yl)-N-(2-ethoxyphenyl)guanidine (CAS 351190-36-8)
- (S)-2-(Benzo[b]thiophen-2-yl)-4-isopropyl-4,5-dihydrooxazole (CAS 541549-94-4)
- 5-(Isoxazol-5-yl)-2-methylthiophene-3-sulfonyl chloride (CAS 1282484-31-4)
- (2,5,7-Trimethyl-1h-indol-3-yl)acetic acid (CAS 91957-25-4)
- [Formaldehyde Schiff-base]-Semaglutide Impurity 136 X TFA Salt (CAS CATO-C4X-2226136)
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