Tiotropium impurity 45 CAS 535995-21-2
| CAS No. | 535995-21-2 |
| Molecular Formula | C19H25NO5 |
| Molecular Weight | 347.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tiotropium impurity 45 (CAS 535995-21-2, C19H25NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tiotropium impurity 45 (C19H25NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 347.41 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Tiotropium impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H25NO5 |
| Molecular Weight | 347.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 1 |
Related Tiotropium Standards
- Tiotropium EP Impurity D (CAS 136310-66-2)
- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- Tiotropium Bromide Impurity 20 (CAS 1459721-06-2)
- Tiotropium impurity 43 (CAS CATO-C4X-176443)
- Tiotropium impurity 42 (CAS 2512209-13-9)
- Tiotropium impurity 50 (CAS CATO-C4X-176450)
- Tiotropium impurity 48 (CAS CATO-C4X-176448)
- Tiotropium Bromide EP Impurity K (CAS CATO-C4X-176411)
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