Tenofovir Alafenamide Impurity 65 CAS CATO-C4X-179765
| CAS No. | CATO-C4X-179765 |
| Molecular Formula | C16H20N5O4P |
| Molecular Weight | 377.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tenofovir Alafenamide Impurity 65 (CAS CATO-C4X-179765, C16H20N5O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tenofovir Alafenamide Impurity 65 (C16H20N5O4P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tenofovir Alafenamide Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N5O4P |
| Molecular Weight | 377.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 11 (CAS CATO-C4X-179711)
- Tenofovir Disoproxil Impurity 61 (CAS CATO-C4X-107661)
- Tenofovir alafenamide Impurity 90 (CAS CATO-C4X-179790)
- Tenofovir Monophosphate (CAS 206646-04-0)
- Tenofovir Alafenamide Impurity 18 (CAS 379270-35-6)
- Tenofovir Alafenamide Impurity 28 (CAS CATO-C4X-179728)
- Tenofovir Alafenamide 64 (CAS CATO-C4X-179764)
- Tenofovir alafenamide Impurity 96 (CAS CATO-C4X-179796)
Recommended Standards
- Marbofloxacin Impurity 10 (CAS CATO-C4X-180010)
- tert-Butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)bicyclo[1.1.1]pentan-1-yl)piperidine-1-carboxylate (CAS 2826263-67-4)
- Methyl 8-isopropyl-4-(((trifluoromethyl)sulfonyl)oxy)quinoline-2-carboxylate (CAS 187401-27-0)
- N-(2-(3-Fluorophenyl)benzo[d]oxazol-5-yl)-3-nitrobenzamide (CAS 331447-20-2)
- Cefpodoxime Proxetil Impurity 25 (CAS CATO-C4X-157938)
- Naltrexone impurity 37 (CAS CATO-C4X-147537)
- Vibegron Impurity 3 (CAS 1009092-91-4)
- 3-(3,3-Difluoroazetidin-1-yl)piperidine (CAS 2366179-60-2)
- Ethyl 6-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 111185-65-0)
- 4-Oxo-4-[N-(pyridine-4-carbonyl)-hydrazino]-butyric acid (CAS 327026-20-0)
- 4-(((3,3-Dimethylbutan-2-yl)amino)methyl)benzoic acid (CAS 1569537-18-3)
- 2-(4-Chloro-6-fluoropyridin-2-yl)ethan-1-amine (CAS 1393584-23-0)
- 2-Chloro-7-methyl-7H-purin-8(9H)-one (CAS 1273315-19-7)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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