Miconazole EP Impurity I HCl CAS CATO-C4X-180210
| CAS No. | CATO-C4X-180210 |
| Molecular Formula | C18H15Cl3N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Miconazole EP Impurity I HCl (CAS CATO-C4X-180210, C18H15Cl3N2OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Miconazole EP Impurity I HCl (C18H15Cl3N2OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Miconazole EP Impurity I HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15Cl3N2O HCl |
| Molecular Weight | 418.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Miconazole Standards
- Miconazole-d5 Nitrate (CAS 1216653-51-8)
- Miconazole EP Impurity H (CAS 181931-30-6)
- Miconazole EP Impurity H (CAS 181931-30-6（free base）)
- Miconazole Impurity H nitarte salt (CAS 203264-09-9)
- Miconazole Nitrate (CAS 228321-87-7)
- Miconazole (CAS 22916-47-8)
- Miconazole EP Impurity D (CAS 24168-96-5)
- Miconazole EP Impurity I (CAS 24169-00-4)
Recommended Standards
- Anastrozole Impurity 32 (CAS CATO-C4X-123932)
- Alectinib impurity 22 (CAS CATO-C4X-283622)
- Ivacaftor Impurity 3 (CAS 873055-57-3)
- 5-Bromo-3-methyl-2-(methylthio)pyridine (CAS 1289270-74-1)
- 9-(3-Bromophenyl)anthracene (CAS 859331-70-7)
- [1,2,4]Triazolo[4,3-a]pyridine-6-boronic Acid Pinacol Ester (CAS 1314137-24-0)
- 5-Bromo-6-phenyl-2-(pyridin-2-yl)imidazo[2,1-b][1,3,4]thiadiazole (CAS 666826-38-6)
- 3-Nitro-5-(o-tolyloxy)aniline (CAS 208122-68-3)
- N-((5-bromopyridin-3-yl)methyl)-2-methylpropan-1-amine (CAS 1183244-40-7)
- Semaglutide impurity 37 (CAS CATO-C4X-222637)
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