Ivacaftor Impurity 3 CAS 873055-57-3
| CAS No. | 873055-57-3 |
| Molecular Formula | C14H21NO3 |
| Molecular Weight | 251.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C14H21NO3, Ivacaftor Impurity 3 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Ivacaftor Impurity 3 (CAS 873055-57-3, C14H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ivacaftor Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H21NO3 |
| Molecular Weight | 251.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Ivacaftor Standards
- Ivacaftor Impurity 14 (CAS 54535-22-7)
- Ivacaftor Impurity 10 (CAS 873055-58-4)
- Ivacaftor impurity 17 (CAS CATO-C4X-296417)
- Ivacaftor Impurity 7 (CAS 52980-28-6)
- Ivacaftor Impurity 9 (CAS 26892-90-0)
- Ivacaftor Impurity 12 (CAS CATO-C4X-296412)
- Ivacaftor Impurity 4 (CAS 873055-55-1)
- Ivacaftor Impurity 11 (CAS 13721-01-2)
Recommended Standards
- Sacubitril impurity 41 (CAS 1038924-61-6)
- Nemonoxacin Impurity 37 (CAS CATO-C4X-312837)
- Procaine Impurity 29 (CAS CATO-C4X-262329)
- Furmecyclox (CAS 60568-05-0)
- Valproate Impurity 46 (CAS 2985-35-5)
- Testosterone Impurity 5 (CAS 1099-87-2 (Anhydrous CAS))
- Metoclopramide Impurity 36 (CAS 82689-92-7（free base）)
- 2H-Isoxazolo[4,5-b]indole (CAS 54618-57-4)
- n-(4-Bromophenyl)-3-(tetrahydrofuran-2-yl)propanamide (CAS 1147643-58-0)
- Boc-Lys(Z)-OH (CAS 2389-45-9)
- (Heptafluoroisopropyl)benzene (CAS 378-34-7)
- (R)-4-Ethyl-3,4-dihydro-2H-pyrido[2,3-b][1,4,5]oxathiazepine 1,1-dioxide (CAS 1799974-85-8)
- methyl 2-[3-(4-hydroxybut-1-ynyl)phenyl]-2-methyl-propanoate (CAS 2614598-91-1)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
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