Adapalene impurity 21 CAS CATO-C4X-180921
| CAS No. | CATO-C4X-180921 |
| Molecular Formula | C46H62O3 |
| Molecular Weight | 662.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Adapalene impurity 21.
Adapalene impurity 21 (CAS CATO-C4X-180921) is a certified pharmaceutical impurity reference standard with the molecular formula C46H62O3 and a molecular weight of 662.98 g/mol.
The molecular framework of Adapalene impurity 21 (C46H62O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Adapalene impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C46H62O3 |
| Molecular Weight | 662.98 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Adapalene Standards
- Adapalene Impurity 23 (CAS CATO-C4X-180923)
- Adapalene Impurity 15 (CAS CATO-C4X-180915)
- Adapalene Impurity 22 (CAS CATO-C4X-180922)
- Adapalene EP Impurity D (CAS 932033-57-3)
- Adapalene Impurity 16 (CAS CATO-C4X-180916)
- Adapalene EP Impurity B (CAS 1346599-76-5)
- Adapalene Impurity 5 (CAS 106685-41-0)
- Adapalene-d6 (CAS CATO-C4X-180918)
Recommended Standards
- 3,3′-Bis[3,5-bis(1,1-dimethylethyl)phenyl][1,1′-binaphthalene]-2,2′-diol (CAS 2031124-69-1)
- (R)-3,3'-Bis(3,5-di-tert-butylphenyl)-[1,1'-binaphthalene]-2,2'-diol (CAS 756491-53-9)
- Oryzanol Impurity 3 (CAS CATO-C4X-28613)
- (R)-3,3’-Bis(3,5-di-tert-butyl-4-methoxyphenyl)-[1,1’-binaphthalene]-2,2’-diol (CAS 1353682-93-5)
- Tadalafil Impurity 148 (CAS 385769-86-8)
- Tandospirone Impurity 16 (CAS CATO-C4X-187516)
- Etoricoxib Impurity 78 (CAS 99055-63-7)
- N-(3,4-Dichlorophenyl)-N'-methyl-N'-phenylpropanediamide (CAS 338392-29-3)
- 3-(Cyclopropylmethyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-7-carboxylic acid (CAS 1095823-30-5)
- 4-(Dimethylamino)-3-hydroxybenzenesulfonamide (CAS 1243371-92-7)
- 4-Benzoyl-1-benzylpyrrolidine-3-carboxylic acid (CAS 885958-79-2)
- Dapagliflozin Impurity 43 (CAS 1384242-56-1)
- 5-((6-((E)-3-(5-((2R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphino)oxy)tetrahydrofuran-2-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acrylamido)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate) (CAS 289712-99-8)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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