Adapalene EP Impurity B CAS 1346599-76-5
| CAS No. | 1346599-76-5 |
| Molecular Formula | C28H28O4 |
| Molecular Weight | 428.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Adapalene EP Impurity B.
As a process- or degradation-related impurity, Adapalene EP Impurity B (CAS 1346599-76-5, C28H28O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H28O4, Adapalene EP Impurity B contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 428.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Adapalene EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H28O4 |
| Molecular Weight | 428.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
Related Adapalene Standards
- Adapalene Impurity 5 (CAS 106685-41-0)
- Adapalene-d6 (CAS CATO-C4X-180918)
- Adapalene Impurity 12 (CAS 1063712-23-1)
- Adapalene Impurity 13 (CAS 106685-43-2)
- Adapalene (CAS 106685-40-9)
- Adapalene Impurity 16 (CAS CATO-C4X-180916)
- Adapalene EP Impurity D (CAS 932033-57-3)
- Adapalene Impurity 10 (CAS 161912-38-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com