Suvorexant Impurity 8 CAS CATO-C4X-18128
| CAS No. | CATO-C4X-18128 |
| Molecular Formula | C22H28ClN3O4 |
| Molecular Weight | 433.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Suvorexant Impurity 8.
As a process- or degradation-related impurity, Suvorexant Impurity 8 (CAS CATO-C4X-18128, C22H28ClN3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Suvorexant Impurity 8 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 433.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28ClN3O4 |
| Molecular Weight | 433.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Suvorexant Standards
- Suvorexant Impurity 23 (CAS CATO-C4X-181223)
- 【禁售不询】Suvorexant (CAS 1030377-33-3)
- Suvorexant Impurity 1 (CAS 1030377-80-0)
- Suvorexant Impurity 19 (CAS 2762965-03-5)
- Suvorexant Impurity 2 (CAS 1276666-19-3)
- Suvorexant Impurity 43 (CAS 1234707-20-0)
- Suvorexant Impurity 6 (CAS CATO-C4X-18126)
- Suvorexant Impurity 5 (CAS 2762965-04-6)
Recommended Standards
- Avanafil Impurity 14 (CAS CATO-C4X-111814)
- Tert-butyl ((6-(7-chlorothieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)(2-methoxyethyl)carbamate (CAS 1123838-02-7)
- 2-Chloro-N-(2,2-diphenylethyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (CAS 264608-14-2)
- 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-1-(p-tolyl)ethanone (CAS 476485-84-4)
- Oseltamivir Impurity 207 (CAS CATO-C4X-1720207)
- Milrinone Impurity 6 (CAS 1443528-66-2)
- Nicotinic Acid EP Impurity C HCl (CAS 2024-89-7)
- 1,2-Dibromo-1,1,2-trifluoro-2-(trifluoromethoxy)ethane (CAS 2356-57-2)
- 2-phenyl-5H,6H,7H,8H-imidazo[1,2-a]pyrimidine hydrochloride (CAS 1803571-96-1)
- Thalidomide-PEG2-C2-NH2 (TFA) (CAS 2097509-36-7)
- 2-Chloro-3-ethynyl-6-methylpyridine (CAS 1256794-73-6)
- 2-Iodo-4-(trifluoromethyl)benzyl bromide (CAS 939758-31-3)
- methyl 4-[(phenoxycarbonyl)amino]benzoate (CAS 101097-65-8)
- Palmitoyl Tripeptide-8 TFA salt (CAS 936544-53-5)
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