Nintedanib Impurity 100 TFA CAS CATO-C4X-1814100
| CAS No. | CATO-C4X-1814100 |
| Molecular Formula | C13H18N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Nintedanib Impurity 100 TFA under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Nintedanib Impurity 100 TFA (CAS CATO-C4X-1814100), a pharmacopoeial impurity reference standard (molecular formula C13H18N4O3C2HF3O2, MW 392.33 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nintedanib Impurity 100 TFA (C13H18N4O3C2HF3O2) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H18N4O3 C2HF3O2 |
| Molecular Weight | 392.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Nintedanib Standards
- Nintedanib Impurity 158 (CAS 1023942-14-4)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 6 (CAS 1139453-98-7)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Orforglipron impurity 102 (CAS 3047292-99-6)
- Relebactam Impurity 100 (CAS 2089462-50-8)
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- (4S,4'S)-2,2'-Cyclobutylidenebis[4,5-dihydro-4-(phenylmethyl)oxazole] (CAS 1003886-03-0)
- 6-Methoxy-3-quinolinecarboxaldehyde (CAS 13669-60-8)
- 1-(3,5-Dichlorophenyl)-3-(2,3-dimethylphenyl)propan-1-one (CAS 898793-31-2)
- 2-(2-Bromoethyl)phenol (CAS 57027-75-5)
- Gastric Inhibitory Polypeptide (1-30) amide (porcine) (CAS 134846-93-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com