Pimavanserin Impurity 48 CAS CATO-C4X-193848
| CAS No. | CATO-C4X-193848 |
| Molecular Formula | C36H48FN3O3 |
| Molecular Weight | 589.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pimavanserin Impurity 48.
Pimavanserin Impurity 48 (CAS CATO-C4X-193848) is a certified pharmaceutical impurity reference standard with the molecular formula C36H48FN3O3 and a molecular weight of 589.78 g/mol.
Pimavanserin Impurity 48 (C36H48FN3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H48FN3O3 |
| Molecular Weight | 589.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Pimavanserin Standards
- Pimavanserin Impurity 49 (CAS CATO-C4X-193849)
- Pimavanserin impurity 55 (CAS CATO-C4X-193855)
- Pimavanserin Impurity 20 (CAS 1134815-71-6)
- Pimavanserin Impurity 11 (CAS CATO-C4X-193811)
- Pimavanserin-d4 (CAS 706779-91-1 (unlabelled))
- Pimavanserin (CAS 706779-91-1)
- Pimavanserin Impurity 32 (CAS CATO-C4X-193832)
- Pimavanserin Impurity 68 (CAS CATO-C4X-193868)
Recommended Standards
- Ebastine Impurity 15 (CAS CATO-C4X-202915)
- (3aS,4S,6aR)-Hexahydro-N-[6-[[6-[[2-(4-hydroxyphenyl)ethyl]amino]-6-oxohexyl]amino]-6-oxohexyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide (CAS 851113-28-5)
- Clarithromycin EP Impurity I (CAS 118058-74-5)
- [S(R)]-N-[(S)-[(3-(Benzyloxy)-2-(dicyclohexylphosphino)phenyl)phenylmethyl]-2-methyl-2-propanesulfinamide (CAS 2565792-64-3)
- Perindopril Impurity 111 (CAS 145513-93-5)
- Indocyanine Green Impurity 20 (CAS 68579-35-1)
- Indocyanine green Impurity 55 (CAS CATO-C4X-250355)
- 3-Chloro-7,8-dihydroxy-4-methyl-2H-chromen-2-one (CAS 19149-43-0)
- 4-Ethyl-1-(prop-2-yn-1-yl)cyclohexane-1-carboxylic acid (CAS 1523495-00-2)
- 3,3-Dimethyl-2-oxobutanenitrile (CAS 42867-40-3)
- 5-Cyclopropoxy-6-(dimethylamino)-N-methylnicotinamide (CAS 1243402-18-7)
- 2-Bromo-4-(2-methoxy-ethoxy)-phenol (CAS 52076-14-9)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-isopropylphenyl)acetamide (CAS 585557-33-1)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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