Pimavanserin Impurity 52 CAS CATO-C4X-193852
| CAS No. | CATO-C4X-193852 |
| Molecular Formula | C14H21FN2 |
| Molecular Weight | 236.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Pimavanserin Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Pimavanserin Impurity 52 (CAS CATO-C4X-193852, C14H21FN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pimavanserin Impurity 52 (C14H21FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H21FN2 |
| Molecular Weight | 236.33 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Pimavanserin Standards
- Pimavanserin Impurity 37 (CAS CATO-C4X-193837)
- Pimavanserin Impurity 3 (CAS 134227-41-1)
- Pimavanserin Impurity 17 (CAS CATO-C4X-193817)
- Pimavanserin Impurity 4 (CAS 428819-12-9)
- Pimavanserin Impurity 1 (CAS 107456-06-4)
- Pimavanserin Impurity 46 (CAS 1173710-95-6)
- Pimavanserin Impurity 45 (CAS 71022-60-1)
- Pimavanserin Impurity 34 (CAS 415950-74-2)
Recommended Standards
- Canagliflozin Impurity 99 (CAS CATO-C4X-112399)
- 1,2-Dibromo-3-Chloropropane (CAS 96-12-8)
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- Evandamine (CAS 100035-75-4)
- Pemetrexed Impurity 72 TFA salt (CAS 884381-72-0（free base）)
- Milnacipran Impurity 22 (CAS 2254103-64-3)
- Efavirenz Impurity (6-chloro-4-[2-(2-methylcyclopropyl)ethynyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) (CAS 1217623-65-8)
- Sivelestat sodium impurity 22 (CAS 1655497-02-1)
- 78509-29-2 4-Chloro-2,7,8-trimethylquinoline DTXSID40587946 (CAS 78509-29-2)
- 4-Bromo-1-ethyl-1,2-dihydropyridin-2-one (CAS 832735-58-7)
- 4-((3-Bromophenoxy)methyl)-1,2-dichlorobenzene (CAS 1039840-88-4)
- (3R,4S)-(3-Boc-amino)-4-fluoropyrrolidine (CAS 1033718-91-0)
- 2-Bromo-4-chloro-6-fluorobiphenyl (CAS 2244107-72-8)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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