Varenicline Impurity 68 CAS CATO-C4X-196268
| CAS No. | CATO-C4X-196268 |
| Molecular Formula | C13H13N3O2 |
| Molecular Weight | 243.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Varenicline Impurity 68 (CAS CATO-C4X-196268, C13H13N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Varenicline Impurity 68 (C13H13N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H13N3O2 |
| Molecular Weight | 243.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Varenicline Standards
- Varenicline Dioxo Impurity (CAS 357424-07-8)
- Varenicline Impurity 16 (CAS 1337563-47-9)
- Varenicline Impurity 58 (CAS CATO-C4X-196258)
- Varenicline Impurity 25 (CAS CATO-C4X-196225)
- Varenicline Nitroso Impurity 36 (CAS CATO-C4X-196236)
- Varenicline Impurity 71 (CAS CATO-C4X-196271)
- Varenicline Impurity 13 (CAS 2755871-02-2)
- Varenicline Impurity 44 (CAS CATO-C4X-196244)
Recommended Standards
- Sepiapterin Impurity 11 (CAS 1177884-36-4)
- Ozenoxacin Impurity 60 (CAS 1267085-60-8)
- Pranoprofen Impurity 54 (CAS CATO-C4X-181154)
- Finerenone Impurity 194 (CAS CATO-C4X-2880194)
- Linzagolix Impurity 3 (CAS 2168201-68-9)
- Omadacycline Impurity 49 (CAS CATO-C4X-285749)
- Belumosudil Impurity N1 (CAS 911417-26-0)
- Zeatin riboside (CAS 28542-78-1)
- Dasatinib Impurity 68 (CAS CATO-C4X-160768)
- Dyclonine Impurity 12 (CAS 91763-92-7)
- N-(2-((2-Hydroxyethyl)amino)cyclohexyl)acetamide (CAS 1353976-09-6)
- 2-Chloro-n-cyclohexyl-n-methylpyrimidin-4-amine (CAS 1248370-43-5)
- 2-[3-(3-chlorophenyl)-2,4-dioxoimidazolidin-1-yl]acetic acid (CAS 1411650-70-8)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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