Bumetanide Impurity 77 CAS CATO-C4X-198677
| CAS No. | CATO-C4X-198677 |
| Molecular Formula | C17H18ClNO3 |
| Molecular Weight | 319.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Bumetanide Impurity 77 (C17H18ClNO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 319.78 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Bumetanide Impurity 77 (CAS CATO-C4X-198677) is a certified pharmaceutical impurity reference standard with the molecular formula C17H18ClNO3 and a molecular weight of 319.78 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18ClNO3 |
| Molecular Weight | 319.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 34 (CAS CATO-C4X-198634)
- Bumetanide Impurity 63 (CAS CATO-C4X-198663)
- Bumetanide Impurity 46 (CAS 28328-56-5)
- Bumetanide Impurity 102 (CAS CATO-C4X-1986102)
- Bumetanide Impurity 130 (CAS CATO-C4X-1986130)
- Bumetanide Impurity 27 (CAS CATO-C4X-198627)
- Bumetanide Impurity 22 (CAS CATO-C4X-198622)
- Bumetanide Impurity 74 (CAS CATO-C4X-198674)
Recommended Standards
- Pranoprofen Impurity 23 (CAS CATO-C4X-181123)
- 5-((1-Methyl-1h-pyrazole-4-carboxamido)methyl)thiophene-2-sulfonyl chloride (CAS 1152948-99-6)
- Ketorolac Impurity 76 (CAS CATO-C4X-166976)
- 1-(2-Chloro-4-methylphenyl)-3-(2-((6-methylpyridazin-3-yl)amino)ethyl)urea (CAS 1173041-97-8)
- Gefitinib Impurity 45 (CAS 350-30-1)
- Azelastine Impurity 18 (CAS CATO-C4X-139618)
- Nizatidine EP Impurity A (CAS 54252-45-8)
- rel-(S)-5-(Hydroxymethyl)-3-((R)-1-phenylethyl)oxazolidin-2-one (CAS 480424-72-4)
- 5-Bromo-2-methylisoindoline-1,3-dione (CAS 90224-73-0)
- 5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran-d (CAS 1185079-36-0)
- 1-(2-Chloro-6-fluorophenyl)cyclopropan-1-ol (CAS 1249651-22-6)
- 4-Hydroxy-2-mercapto-5-methylpyrido[2,3-d]pyrimidine-7-carboxylic acid (CAS 1245570-19-7)
- {3-[(2-methylmorpholin-4-yl)methyl]phenyl}methanamine (CAS 954274-69-2)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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