Bumetanide Impurity 46 CAS 28328-56-5
| CAS No. | 28328-56-5 |
| Molecular Formula | C14H14N2O5S |
| Molecular Weight | 322.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Bumetanide Impurity 46 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 322.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Bumetanide Impurity 46 (CAS 28328-56-5, C14H14N2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14N2O5S |
| Molecular Weight | 322.34 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 63 (CAS CATO-C4X-198663)
- Bumetanide Impurity 34 (CAS CATO-C4X-198634)
- Bumetanide Impurity 102 (CAS CATO-C4X-1986102)
- Bumetanide Impurity 130 (CAS CATO-C4X-1986130)
- Bumetanide Impurity 27 (CAS CATO-C4X-198627)
- Bumetanide Impurity 77 (CAS CATO-C4X-198677)
- Bumetanide Impurity 22 (CAS CATO-C4X-198622)
- Bumetanide Impurity 74 (CAS CATO-C4X-198674)
Recommended Standards
- Flupentixol Impurity 39 (CAS 850808-70-7)
- Anthracene-9,10-diylbis(methylene) diacetate (CAS 10273-84-4)
- tert-Butyl 4-(8-fluoro[1,2,4]triazolo[4,3-c]pyrimidin-5-yl)piperazine-1-carboxylate (CAS 2096987-10-7)
- 6,7-Dimethoxy-4-(p-tolyl)-2-naphthoic acid (CAS 109933-59-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Vortioxetine Impurity 53 (CAS CATO-C4X-105653)
- Cefaclor Impurity 17 (CAS CATO-C4X-127017)
- 1-(5-Phenyl-1-tosyl-1H-pyrrol-2-yl)ethan-1-one (CAS 827024-08-8)
- 3-Ethenylthiophene-2-carbaldehyde (CAS 1089665-09-7)
- 5-(2,5-Dihydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione (CAS 137361-19-4)
- (S)-N-Ethyl-2-(pyrrolidin-3-yloxy)pyrimidin-4-amine hydrochloride (CAS 1417789-16-2)
- 2-(1-(4-Fluorophenyl)ethylidene)malononitrile (CAS 579-48-6)
- 3-(4-Bromo-3-fluorophenyl)-2-chloro-1-propene (CAS 951888-41-8)
- Semaglutide impurity 50 (CAS 2773558-66-8)
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