Crisaborole impurity 114 CAS CATO-C4X-2021114
| CAS No. | CATO-C4X-2021114 |
| Molecular Formula | C22H24BNO5 |
| Molecular Weight | 393.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Crisaborole impurity 114 (C22H24BNO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.5, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 393.24 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Crisaborole impurity 114 (CAS CATO-C4X-2021114) is a certified pharmaceutical impurity reference standard with the molecular formula C22H24BNO5 and a molecular weight of 393.24 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Crisaborole impurity 114 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H24BNO5 |
| Molecular Weight | 393.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 106 (CAS CATO-C4X-2021106)
- Crisaborole impurity 107 (CAS CATO-C4X-2021107)
- Crisaborole impurity 122 (CAS CATO-C4X-2021122)
- Crisaborole Impurity 138 (CAS CATO-C4X-2021138)
- Crisaborole impurity 157 (CAS CATO-C4X-2021157)
- Crisaborole impurity 159 (CAS CATO-C4X-2021159)
- Crisaborole Impurity 39 (CAS 2227126-13-6)
- Crisaborole Impurity 59 (CAS CATO-C4X-202159)
Recommended Standards
- Chlorthiophos-sulfone (CAS 25900-20-3)
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- 5-(2-Amino-6-(4-bromophenyl)pyrimidin-4-yl)quinolin-8-ol (CAS 833488-14-5)
- 3-[(6-Iodo-2,3-dihydrobenzotriazol-1-yl)methyl]thiane 1,1-dioxide (CAS 2721204-06-2)
- Mirogabalin Impurity 176 (CAS CATO-C4X-2924176)
- Levocarnitine Impurity N11 (CAS 101396-87-6)
- Vonoprazan Impurity 277 (CAS CATO-C4X-1020277)
- (5R)-1-[(tert-Butoxy)carbonyl]-5-methylpyrrolidine-3-carboxylic acid (CAS 2102403-69-8)
- (R)-7-Methyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-3-ol (CAS 188753-42-6)
- 1-(pyridin-3-yl)propan-2-one (CAS 6302-03-0)
- 4-Chloro-5-methylpyridin-2-ol (CAS 1227592-83-7)
- 3-((4-Hydroxyphenyl)sulfinyl)-2,2-dimethylpropanoic acid (CAS 1171935-44-6)
- 1-Methyl-5-(prop-2-yn-1-yloxy)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 318284-67-2)
- Peptide YY (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 81858-94-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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