Crisaborole Impurity 59 CAS CATO-C4X-202159
| CAS No. | CATO-C4X-202159 |
| Molecular Formula | C18H18BrNO4 |
| Molecular Weight | 392.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Crisaborole Impurity 59 (CAS CATO-C4X-202159) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18BrNO4 and a molecular weight of 392.24 g/mol.
Based on its molecular formula C18H18BrNO4, Crisaborole Impurity 59 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 392.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H18BrNO4 |
| Molecular Weight | 392.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole impurity 106 (CAS CATO-C4X-2021106)
- Crisaborole impurity 107 (CAS CATO-C4X-2021107)
- Crisaborole impurity 114 (CAS CATO-C4X-2021114)
- Crisaborole impurity 122 (CAS CATO-C4X-2021122)
- Crisaborole Impurity 138 (CAS CATO-C4X-2021138)
- Crisaborole impurity 157 (CAS CATO-C4X-2021157)
- Crisaborole impurity 159 (CAS CATO-C4X-2021159)
- Crisaborole Impurity 39 (CAS 2227126-13-6)
Recommended Standards
- n-Benzyl-2-(5-bromo-2-ethoxy-4-formylphenoxy)acetamide (CAS 832674-54-1)
- Disperse Orange 37 (CAS 13301-61-6)
- N-[4-[(4-Bromophenyl)sulfanyl]-6-(trifluoromethyl)-2-pyrimidinyl]-N-isopropylamine (CAS 339011-52-8)
- (3-(4-(Pyren-1-yl)butanoyl)phenyl)boronic acid (CAS 849611-34-3)
- Metoclopramide impurity 63 (CAS CATO-C4X-141563)
- Abemaciclib Impurity 177 (CAS CATO-C4X-2937177)
- Everolimus Impurity 5 (CAS CATO-C4X-11225)
- 3-(3-Bromophenyl)-1-cyclopropylpiperazine (CAS 1248907-95-0)
- 4-Acetylnicotinonitrile (CAS 1211528-85-6)
- Bromocriptine Impurity 11 (CAS CATO-C4X-136111)
- 3-Bromo-5-(difluoromethoxy)pyridine (CAS 342602-27-1)
- 2-Chloro-N-(3-(3-methyl-1H-indol-1-yl)propyl)acetamide (CAS 61985-40-8)
- 2,3,4,5-Tetrafluorobenzyl bromide (CAS 53001-71-1)
- Casein kinase II peptide Substrate (CAS 154444-98-1)
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