Crisaborole Impurity 28 CAS CATO-C4X-202128
| CAS No. | CATO-C4X-202128 |
| Molecular Formula | C25H20BrNO6 |
| Molecular Weight | 510.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 28 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 28 (CAS CATO-C4X-202128) is a certified pharmaceutical impurity reference standard with the molecular formula C25H20BrNO6 and a molecular weight of 510.33 g/mol.
Structurally, Crisaborole Impurity 28 (C25H20BrNO6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 510.33 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crisaborole Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H20BrNO6 |
| Molecular Weight | 510.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 85 (CAS CATO-C4X-202185)
- Crisaborole lmpurity 86 (CAS CATO-C4X-202186)
- Crisaborole Impurity 133 (CAS CATO-C4X-2021133)
- Crisaborole Impurity 139 (CAS CATO-C4X-2021139)
- Crisaborole Impurity 71 (CAS CATO-C4X-202171)
- Crisaborole lmpurity 80 (CAS CATO-C4X-202180)
- Crisaborole Impurity 49 (CAS CATO-C4X-2021149)
- Crisaborole Impurity 53 (CAS 2850341-51-2)
Recommended Standards
- 3-((3,4-Dichlorobenzyl)sulfonyl)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide (CAS 251097-53-7)
- Dodecyl 4,6-dibromothieno[3,4-b]thiophene-2-carboxylate (CAS 1098102-93-2)
- 3-((2,6-Dichlorobenzyl)sulfonyl)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide (CAS 251097-54-8)
- Sitagliptin Impurity 165 (CAS CATO-C4X-1144165)
- Hydroxychloroquine Impurity 90 (CAS CATO-C4X-183590)
- Baloxavir Marboxil Impurity 190 (CAS CATO-C4X-2108190)
- Enalapril EP Impurity C（Hydrate） (CAS 84680-54-6)
- 4-(6-Amino-4-hydroxy-2-methyl-quinolin-3-yl)-butan-2-one (CAS 37062-87-6)
- 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carbonitrile (CAS 947305-16-0)
- 2-Hexyladamantan-2-ol (CAS 853179-56-3)
- 2,3-Dihydro-1H-benzo[d]imidazole (CAS 4746-67-2)
- 3,3,3-Trifluoropropyl formate (CAS 1344118-09-7)
- 5-Fluoro-2-isothiocyanatopyridine (CAS 1103425-74-6)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
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