Crisaborole Impurity 49 CAS CATO-C4X-2021149
| CAS No. | CATO-C4X-2021149 |
| Molecular Formula | C27H30BrNO3Si |
| Molecular Weight | 524.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Crisaborole Impurity 49 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Crisaborole Impurity 49 (CAS CATO-C4X-2021149) is a high-purity analytical reference standard with the molecular formula C27H30BrNO3Si and a molecular weight of 524.52 g/mol.
The molecular framework of Crisaborole Impurity 49 (C27H30BrNO3Si) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Crisaborole Impurity 49 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H30BrNO3Si |
| Molecular Weight | 524.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole Impurity 71 (CAS CATO-C4X-202171)
- Crisaborole Impurity 139 (CAS CATO-C4X-2021139)
- Crisaborole lmpurity 86 (CAS CATO-C4X-202186)
- Crisaborole Impurity 53 (CAS 2850341-51-2)
- Crisaborole lmpurity 85 (CAS CATO-C4X-202185)
- Crisaborole Impurity 28 (CAS CATO-C4X-202128)
- Crisaborole impurity 130 (CAS CATO-C4X-2021130)
- Crisaborole lmpurity 88 (CAS CATO-C4X-202188)
Recommended Standards
- Nicardipine Impurity 65 (CAS CATO-C4X-171065)
- 4-Bromo-N,N-bis(4-(hexyloxy)phenyl)aniline (CAS 1092363-75-1)
- Azilsartan Impurity 71 (CAS CATO-C4X-109671)
- 1,1'-[Dithiobis(1-oxo-2,1-ethanediyl)]bis[glycylglycyl-glycine (CAS 174155-75-0)
- Bis(4-(2-methoxyphenyl)piperazine-1-carboximidamide), sulfuric acid (CAS 1354949-56-6)
- 1-((4-Fluorotetrahydro-2H-pyran-4-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1488389-14-5)
- (2-Amino-1-phenylpropyl)dimethylamine (CAS 104177-54-0)
- 6-(4-Fluorophenyl)-2-[(4-methoxyphenyl)sulfanyl]pyridine-3-carbonitrile (CAS 252059-94-2)
- 2,2-Di(1H-indol-3-yl)ethyl acetate (CAS 88321-08-8)
- trans-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)methanol (CAS 145912-65-8)
- 1-Ethylpiperazine (CAS 5308-25-8)
- 3-(2,2-Dichlorovinyl)-N-(2,4-dimethylphenyl)-2,2-dimethylcyclopropane-1-carboxamide (CAS 297146-47-5)
- 4-Chloro-1-(2,4-dichlorobenzyl)-3-isothiocyanato-1h-pyrazole (CAS 1004193-33-2)
- [3-31]-Semaglutide D (CAS C152H230N42O47)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com